Herpes zoster complicating bortezomib therapy of relapsed/refractory indolent B-cell and mantle cell lymphoma: an analysis of two phase II trials

    Authors

    M. Solh; R. I. Fisher; A. Goy; S. de Vos; S. H. Bernstein; D. L. Esseltine; R. Neuwirth;V. A. Morrison

    Comments

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    Abbreviated Journal Title

    Leuk. Lymphoma

    Keywords

    Herpes zoster; bortezomib; non-Hodgkin lymphoma; mantle cell lymphoma; MULTIPLE-MYELOMA; PLUS MELPHALAN; DEXAMETHASONE; PREDNISONE; ACYCLOVIR; Oncology; Hematology

    Abstract

    The incidence of herpes zoster (HZ) in patients with non-Hodgkin lymphoma (NHL) receiving bortezomib-based therapy has not been well studied. We reviewed data from two phase II trials in which bortezomib was administered to 236 patients, median age 65 years, with relapsed/refractory mantle cell or indolent NHL. HZ occurred in 24 patients (10.2%) overall, with a comparable incidence in NHL histologic subgroups. Median time to HZ was 39 (range, 11-206) days. In total, 71% of patients who developed HZ were aged > = 65 years, compared to 48% without HZ (p = 0.03). Patients with HZ were more likely to have had received > = 2 lines of therapy (63% vs. 47%, p = 0.16). Six (25%) of the patients who developed HZ had received purine analogs, compared with 34 (16%) patients without HZ (p = 0.27). As the occurrence of HZ may complicate the course of indolent or mantle cell NHL in patients receiving bortezomib-based therapies, these patients, especially the elderly, should be strongly considered for antiviral prophylaxis.

    Journal Title

    Leukemia & Lymphoma

    Volume

    54

    Issue/Number

    10

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    2185

    Last Page

    2189

    WOS Identifier

    WOS:000324589800019

    ISSN

    1042-8194

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