Microfabricated mammalian organ systems and their integration into models of whole animals and humans

    Authors

    J. H. Sung; M. B. Esch; J. M. Prot; C. J. Long; A. Smith; J. J. Hickman;M. L. Shuler

    Comments

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    Abbreviated Journal Title

    Lab Chip

    Keywords

    BLOOD-BRAIN-BARRIER; CELL-CULTURE ANALOG; FLUORESCENCE; OPTICAL-DETECTION; DRUG-SCREENING PLATFORM; TOTAL BIOASSAY SYSTEM; SERUM-FREE MEDIUM; IN-VITRO TISSUE; SKELETAL-MUSCLE; DEFINED SYSTEM; MICROELECTRODE ARRAYS; Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience; & Nanotechnology

    Abstract

    While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry.

    Journal Title

    Lab on a Chip

    Volume

    13

    Issue/Number

    7

    Publication Date

    1-1-2013

    Document Type

    Review

    Language

    English

    First Page

    1201

    Last Page

    1212

    WOS Identifier

    WOS:000315688500001

    ISSN

    1473-0197

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