Abbreviated Journal Title
Infect. Immun.
Keywords
OUTER-MEMBRANE-PROTEIN; NEIGHBOR-JOINING METHOD; TRYPTOPHAN SYNTHASE; SEQUENCE-ANALYSIS; GENOME SEQUENCE; TISSUE TROPISM; STRAINS; GENE; POLYMORPHISMS; SEROVAR; Immunology; Infectious Diseases
Abstract
Chlamydia trachomatis is the leading cause of infectious blindness worldwide and is the most commonly reported pathogen causing sexually transmitted infections. Tarp (translocated actin recruiting phosphoprotein), a type III secreted effector that mediates actin nucleation, is central to C. trachomatis infection. The phylogenetic analysis of tarP from reference strains as well as ocular, genital, and lymphogranuloma venereum (LGV) clinical isolates demonstrated an evolutionary relationship with disease phenotype, with LGV and ocular isolates branched into clades that were separate from the urogenital isolates. The sequence analysis of Tarp indicated a high degree of variability and identified trends within clinical groupings. Tarps from LGV strains contained the highest number of tyrosine-rich repeat regions (up to nine) and the fewest (two) predicted actin binding domains. The converse was noted for Tarp proteins from ocular isolates that contained up to four actin binding domains and as few as one tyrosine-rich repeat region. The results suggest that Tarp is among the few known genes to play a role in C. trachomatis adaptations to specific niches within the host.
Journal Title
Infection and Immunity
Volume
78
Issue/Number
9
Publication Date
1-1-2010
Document Type
Article
Language
English
First Page
3678
Last Page
3688
WOS Identifier
ISSN
0019-9567
Recommended Citation
Lutter, Erika I.; Bonner, Christine; Holland, Martin J.; Suchland, Robert J.; Stamm, Walter E.; Jewett, Travis J.; McClarty, Grant; and Hackstadt, Ted, "Phylogenetic Analysis of Chlamydia trachomatis Tarp and Correlation with Clinical Phenotype" (2010). Faculty Bibliography 2010s. 481.
https://stars.library.ucf.edu/facultybib2010/481
Comments
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