Mechanism of oral tolerance induction to therapeutic proteins

    Authors

    X. M. Wang; A. Sherman; G. X. Liao; K. W. Leong; H. Daniell; C. Terhorst;R. W. Herzog

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Adv. Drug Deliv. Rev.

    Keywords

    Oral tolerance; Dendritic cells; Treg; IL-10; TGF-beta; Tr1; Th3; Nanoparticles; Transgenic plants; Oral delivery; Protein antigen; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INTESTINAL EPITHELIAL-CELLS; PATCH DENDRITIC CELLS; TOXIN B-SUBUNIT; TRANSCRIPTION FACTOR FOXP3; INFLAMMATORY-BOWEL-DISEASE; COLLAGEN-INDUCED ARTHRITIS; Pharmacology & Pharmacy

    Abstract

    Oral tolerance is defined as the specific suppression of humoral and/or cellular immune responses to an antigen by administration of the same antigen through the oral route. Due to its absence of toxicity, easy administration, and antigen specificity, oral tolerance is a very attractive approach to prevent unwanted immune responses that cause a variety of diseases or that complicate treatment of a disease. Many researchers have induced oral tolerance to efficiently treat autoimmune and inflammatory diseases in different animal models. However, clinical trials yielded limited success. Thus, understanding the mechanisms of oral tolerance induction to therapeutic proteins is critical for paving the way for clinical development of oral tolerance protocols. This review will summarize progress on understanding the major underlying tolerance mechanisms and contributors, including antigen presenting cells, regulatory T cells, cytokines, and signaling pathways. Potential applications, examples for therapeutic proteins and disease targets, and recent developments in delivery methods are discussed. (C) 2012 Elsevier B.V. All rights reserved.

    Journal Title

    Advanced Drug Delivery Reviews

    Volume

    65

    Issue/Number

    6

    Publication Date

    1-1-2013

    Document Type

    Review

    Language

    English

    First Page

    759

    Last Page

    773

    WOS Identifier

    WOS:000321420900002

    ISSN

    0169-409X

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