Title

Mechanism of oral tolerance induction to therapeutic proteins

Authors

Authors

X. M. Wang; A. Sherman; G. X. Liao; K. W. Leong; H. Daniell; C. Terhorst;R. W. Herzog

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Adv. Drug Deliv. Rev.

Keywords

Oral tolerance; Dendritic cells; Treg; IL-10; TGF-beta; Tr1; Th3; Nanoparticles; Transgenic plants; Oral delivery; Protein antigen; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INTESTINAL EPITHELIAL-CELLS; PATCH DENDRITIC CELLS; TOXIN B-SUBUNIT; TRANSCRIPTION FACTOR FOXP3; INFLAMMATORY-BOWEL-DISEASE; COLLAGEN-INDUCED ARTHRITIS; Pharmacology & Pharmacy

Abstract

Oral tolerance is defined as the specific suppression of humoral and/or cellular immune responses to an antigen by administration of the same antigen through the oral route. Due to its absence of toxicity, easy administration, and antigen specificity, oral tolerance is a very attractive approach to prevent unwanted immune responses that cause a variety of diseases or that complicate treatment of a disease. Many researchers have induced oral tolerance to efficiently treat autoimmune and inflammatory diseases in different animal models. However, clinical trials yielded limited success. Thus, understanding the mechanisms of oral tolerance induction to therapeutic proteins is critical for paving the way for clinical development of oral tolerance protocols. This review will summarize progress on understanding the major underlying tolerance mechanisms and contributors, including antigen presenting cells, regulatory T cells, cytokines, and signaling pathways. Potential applications, examples for therapeutic proteins and disease targets, and recent developments in delivery methods are discussed. (C) 2012 Elsevier B.V. All rights reserved.

Journal Title

Advanced Drug Delivery Reviews

Volume

65

Issue/Number

6

Publication Date

1-1-2013

Document Type

Review

Language

English

First Page

759

Last Page

773

WOS Identifier

WOS:000321420900002

ISSN

0169-409X

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