Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

    Authors

    M. S. Wason; J. Colon; S. Das; S. Seal; J. Turkson; J. H. Zhao;C. H. Baker

    Comments

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    Abbreviated Journal Title

    Nanomed.-Nanotechnol. Biol. Med.

    Keywords

    Cerium oxide nanoparticles; Radiation; Sensitizer; Pancreatic cancer; ROS; GROWTH-FACTOR RECEPTOR; IN-VITRO; THERAPY; ACID; AMIFOSTINE; PROTECTION; NANOCERIA; BLOCKADE; SILICA; DAMAGE; Nanoscience & Nanotechnology; Medicine, Research & Experimental

    Abstract

    Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhanced radiation-induced reactive oxygen species (ROS) production preferentially in acidic cell-free solutions as well as acidic human pancreatic cancer cells. In acidic environments, CONPs favor the scavenging of superoxide radical over the hydroxyl peroxide resulting in accumulation of the latter whereas in neutral pH CONPs scavenge both. CONP treatment prior to RT markedly potentiated the cancer cell apoptosis both in culture and in tumors and the inhibition of the pancreatic tumor growth without harming the normal tissues or host mice. Taken together, these results identify CONPs as a potentially novel RT-sensitizer as well as protectant for improving pancreatic cancer treatment. (C) 2013 Elsevier Inc. All rights reserved.

    Journal Title

    Nanomedicine-Nanotechnology Biology and Medicine

    Volume

    9

    Issue/Number

    4

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    558

    Last Page

    569

    WOS Identifier

    WOS:000318985600014

    ISSN

    1549-9634

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