High-fructose corn syrup and sucrose have equivalent effects on energy-regulating hormones at normal human consumption levels

    Authors

    Z. P. Yu; J. Lowndes;J. Rippe

    Comments

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    Abbreviated Journal Title

    Nutr. Res.

    Keywords

    Fructose; Added sugar; Metabolic effects; Leptin; Insulin; Active; ghrelin; Obesity; GLUCOSE-SWEETENED BEVERAGES; NORMAL DIETARY CONSUMPTION; CONTROLLED; FEEDING TRIALS; BODY-WEIGHT; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; SERUM-LIPIDS; AMINO-ACIDS; FATTY-ACIDS; FOOD-INTAKE; Nutrition & Dietetics

    Abstract

    Intake of high-fructose corn syrup (HFCS) has been suggested to contribute to the increased prevalence of obesity, whereas a number of studies and organizations have reported metabolic equivalence between HFCS and sucrose. We hypothesized that HFCS and sucrose would have similar effects on energy-regulating hormones and metabolic substrates at normal levels of human consumption and that these values would not change over a 10-week, free-living period at these consumption levels. This was a randomized, prospective, double-blind, parallel group study in which 138 adult men and women consumed 10 weeks of low-fat milk sweetened with either HFCS or sucrose at levels of the 25th, 50th, and 90th percentile population consumption of fructose (the equivalent of 40, 90, or 150 g of sugar per day in a 2000-kcal diet). Before and after the 10-week intervention, 24-hour blood samples were collected. The area under the curve (AUC) for glucose, insulin, leptin, active ghrelin, triglyceride, and uric acid was measured. There were no group differences at baseline or posttesting for all outcomes (interaction, P > .05). The AUC response of glucose, active ghrelin, and uric acid did not change between baseline and posttesting (P > .05), whereas the AUC response of insulin (P < .05), leptin (P < .001), and triglyceride (P < .01) increased over the course of the intervention when the 6 groups were averaged. We conclude that there are no differences in the metabolic effects of HFCS and sucrose when compared at low, medium, and high levels of consumption. (C) 2013 Elsevier Inc. All rights reserved.

    Journal Title

    Nutrition Research

    Volume

    33

    Issue/Number

    12

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    1043

    Last Page

    1052

    WOS Identifier

    WOS:000328013100008

    ISSN

    0271-5317

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