Selective Cell Death by Photochemically Induced pH Imbalance in Cancer Cells

    Authors

    X. L. Yue; C. O. Yanez; S. Yao;K. D. Belfield

    Comments

    Authors: contact us about adding a copy of your work at [email protected]

    Abbreviated Journal Title

    J. Am. Chem. Soc.

    Keywords

    PHOTOINITIATED CATIONIC-POLYMERIZATION; SALTS; TRIARYLSULFONIUM; TRANSPORT; PROSTATE; HYPOXIA; STORAGE; SERIES; Chemistry, Multidisciplinary

    Abstract

    Singlet oxygen sensitized photodynamic therapy (PDT) relies on the concentration of oxygen in the tissue to be treated. Most cancer lesions, however, have poor vasculature and, as a result, are hypoxic, significantly hindering PDT efficacies. An oxygen-independent PDT method may circumvent this limitation. To address this, we prepared sulfonium salts that produced a pH drop within HCT 116 cells via the generation of a photoacid within the cytosol. This process was driven by one- or two-photon absorption (1PA or 2PA) of the endocytosed photoacid generators (PAGs). One of these PAGs, which had a significantly lower dark cytotoxicity and was more efficient in generating a photoacid, effectively induced necrotic cell death in the HCT 116 cells. The data suggest that PAGs may be an attractive alternative PDT modality to selectively induce cell death in oxygen-deprived tissue such as tumors.

    Journal Title

    Journal of the American Chemical Society

    Volume

    135

    Issue/Number

    6

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    2112

    Last Page

    2115

    WOS Identifier

    WOS:000315080100021

    ISSN

    0002-7863

    Share

    COinS
     

    Accessibility Statement

    This item was created or digitized prior to April 24, 2027, or is a reproduction of legacy media created before that date. It is preserved in its original, unmodified state specifically for research, reference, or historical recordkeeping. In accordance with the ADA Title II Final Rule, the University Libraries provides accessible versions of archival materials upon request. To request an accommodation for this item, please submit an accessibility request form.