Selective Cell Death by Photochemically Induced pH Imbalance in Cancer Cells

    Authors

    X. L. Yue; C. O. Yanez; S. Yao;K. D. Belfield

    Comments

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    Abbreviated Journal Title

    J. Am. Chem. Soc.

    Keywords

    PHOTOINITIATED CATIONIC-POLYMERIZATION; SALTS; TRIARYLSULFONIUM; TRANSPORT; PROSTATE; HYPOXIA; STORAGE; SERIES; Chemistry, Multidisciplinary

    Abstract

    Singlet oxygen sensitized photodynamic therapy (PDT) relies on the concentration of oxygen in the tissue to be treated. Most cancer lesions, however, have poor vasculature and, as a result, are hypoxic, significantly hindering PDT efficacies. An oxygen-independent PDT method may circumvent this limitation. To address this, we prepared sulfonium salts that produced a pH drop within HCT 116 cells via the generation of a photoacid within the cytosol. This process was driven by one- or two-photon absorption (1PA or 2PA) of the endocytosed photoacid generators (PAGs). One of these PAGs, which had a significantly lower dark cytotoxicity and was more efficient in generating a photoacid, effectively induced necrotic cell death in the HCT 116 cells. The data suggest that PAGs may be an attractive alternative PDT modality to selectively induce cell death in oxygen-deprived tissue such as tumors.

    Journal Title

    Journal of the American Chemical Society

    Volume

    135

    Issue/Number

    6

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    2112

    Last Page

    2115

    WOS Identifier

    WOS:000315080100021

    ISSN

    0002-7863

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