Title

A moment-based approach for DVH-guided radiotherapy treatment plan optimization

Authors

Authors

M. Zarepisheh; M. Shakourifar; G. Trigila; P. S. Ghomi; S. Couzens; A. Abebe; L. Norena; W. Shang; S. B. Jiang;Y. Zinchenko

Comments

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Abbreviated Journal Title

Phys. Med. Biol.

Keywords

DOSE-VOLUME CONSTRAINTS; RADIATION-THERAPY; FIELD SEGMENTS; BEAM; WEIGHTS; ALGORITHM; RESTRICTIONS; FRAMEWORK; Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging

Abstract

The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.

Journal Title

Physics in Medicine and Biology

Volume

58

Issue/Number

6

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

1869

Last Page

1887

WOS Identifier

WOS:000315735400013

ISSN

0031-9155

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