A moment-based approach for DVH-guided radiotherapy treatment plan optimization

    Authors

    M. Zarepisheh; M. Shakourifar; G. Trigila; P. S. Ghomi; S. Couzens; A. Abebe; L. Norena; W. Shang; S. B. Jiang;Y. Zinchenko

    Comments

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    Abbreviated Journal Title

    Phys. Med. Biol.

    Keywords

    DOSE-VOLUME CONSTRAINTS; RADIATION-THERAPY; FIELD SEGMENTS; BEAM; WEIGHTS; ALGORITHM; RESTRICTIONS; FRAMEWORK; Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging

    Abstract

    The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.

    Journal Title

    Physics in Medicine and Biology

    Volume

    58

    Issue/Number

    6

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    1869

    Last Page

    1887

    WOS Identifier

    WOS:000315735400013

    ISSN

    0031-9155

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