Histopathologic Manifestations of Drug-induced Hepatotoxicity

    Authors

    X. C. Zhang; J. Ouyang;S. N. Thung

    Comments

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    Abbreviated Journal Title

    Clin. Liver Dis.

    Keywords

    Drugs; Drug-induced hepatotoxicity; Liver injury; Pathology; INDUCED LIVER-INJURY; NONCIRRHOTIC PORTAL-HYPERTENSION; SINUSOIDAL; OBSTRUCTION SYNDROME; INDUCED GRANULOMATOUS HEPATITIS; FOCAL NODULAR; HYPERPLASIA; FIBRIN-RING GRANULOMAS; INDUCED CHOLESTATIC HEPATITIS; INFLAMMATORY-BOWEL-DISEASE; STEM-CELL TRANSPLANTATION; TYPE-1; DIABETES-MELLITUS; Gastroenterology & Hepatology

    Abstract

    Drug-induced hepatotoxicity is underrecognized but increasingly identified as causing acute and chronic liver disease. Several prescription drugs, over-the-counter medications, dietary and/or supplementary agents, and herbal products are hepatotoxic. Drug-induced liver injury mimics other primary acute and chronic liver diseases and it should be considered in patients with hepatobiliary disease. Certain drugs result in specific histopathologic patterns of liver injury, which may help in sorting out the responsible drug. The diagnosis of drug-induced hepatotoxicity is challenging. It involves excluding other possible causes, careful medication history, the latent period between drug exposure and symptom onset and/or abnormal liver tests, and histopathologic findings.

    Journal Title

    Clinics in Liver Disease

    Volume

    17

    Issue/Number

    4

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    547

    Last Page

    +

    WOS Identifier

    WOS:000326659500005

    ISSN

    1089-3261

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