Title

Role of Vasopressin and Its Antagonism in Stroke Related Edema

Authors

Authors

P. A. Ameli; N. J. Ameli; D. M. Gubernick; S. Ansari; S. Mohan; I. Satriotomo; A. K. Buckley; C. W. Maxwell; V. H. Nayak;V. S. Hedna

Comments

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Abbreviated Journal Title

J. Neurosci. Res.

Keywords

vasopressin; vasopressin antagonism; stroke; aquaporin; cerebral edema; brain injury; ACUTE ISCHEMIC-STROKE; MIDDLE CEREBRAL-ARTERY; PLASMA; ARGININE-VASOPRESSIN; RELEASE INHIBITOR RU51599; V1A RECEPTOR; ANTAGONIST; CENTRAL-NERVOUS-SYSTEM; INDUCED BRAIN EDEMA; SUBARACHNOID; HEMORRHAGE; CEREBROVASCULAR-DISEASE; AQUAPORIN-4 EXPRESSION; Neurosciences

Abstract

Although many approaches have been tried in the attempt to reduce the devastating impact of stroke, tissue plasminogen activator for thromboembolic stroke is the only proved, effective acute stroke treatment to date. Vasopressin, an acute-phase reactant, is released after brain injury and is partially responsible for the subsequent inflammatory response via activation of divergent pathways. Recently there has been increasing interest in vasopressin because it is implicated in inflammation, cerebral edema, increased intracerebral pressure, and cerebral ion and neurotransmitter dysfunctions after cerebral ischemia. Additionally, copeptin, a byproduct of vasopressin production, may serve as a promising independent marker of tissue damage and prognosis after stroke, thereby corroborating the role of vasopressin in acute brain injury. Thus, vasopressin antagonists have a potential role in early stroke intervention, an effect thought to be mediated via interactions with aquaporin receptors, specifically aquaporin-4. Despite some ambiguity, vasopressin V1a receptor antagonism has been consistently associated with attenuated secondary brain injury and edema in experimental stroke models. The role of the vasopressin V2 receptor remains unclear, but perhaps it is involved in a positive feedback loop for vasopressin expression. Despite the encouraging initial findings we report here, future research is required to characterize further the utility of vasopressin antagonists in treatment of stroke. (C) 2014 Wiley Periodicals, Inc.

Journal Title

Journal of Neuroscience Research

Volume

92

Issue/Number

9

Publication Date

1-1-2014

Document Type

Review

Language

English

First Page

1091

Last Page

1099

WOS Identifier

WOS:000340502800001

ISSN

0360-4012

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