Title
Mathematical Modeling of Patient-Specific Ventricular Assist Device Implantation to Reduce Particulate Embolization Rate to Cerebral Vessels
Abbreviated Journal Title
J. Biomech. Eng.-Trans. ASME
Keywords
circulatory assist devices; stroke; computer applications; circulatory; hemodynamics; brain thrombosis; MOLECULAR-WEIGHT HEPARIN; CIRCULATORY SUPPORT; FLUID-DYNAMICS; BLOOD-FLOW; IN-VIVO; TRANSPLANTATION; ANASTOMOSIS; SYSTEM; Biophysics; Engineering, Biomedical
Abstract
Stroke is the most devastating complication after ventricular assist device (VAD) implantation, with an incidence of 14%-47% despite improvements in device design and anticoagulation. This complication continues to limit the widespread implementation of VAD therapy. Patient-specific computational fluid dynamics (CFD) analysis may elucidate ways to reduce this risk. A patient-specific three-dimensional model of the aortic arch was generated from computed tomography. A 12 mm VAD outflow-graft (VAD-OG) "anastomosed" to the aorta was rendered. CFD was applied to study blood flow patterns. Particle tracks, originating from the VAD, were computed with a Lagrangian phase model and percentage of particles entering the cerebral vessels was calculated. Twelve implantation configurations of the VAD-OG and three particle sizes (2, 4, and 5 mm) were considered. Percentage of particles entering the cerebral vessels ranged from 6% for the descending aorta VAD-OG anastomosis, to 14% for the ascending aorta at 90 deg VAD-OG anastomosis. Values were significantly different among all configurations (X-2 = 3925, p < 0.0001). Shallower and more cephalad anastomoses prevented formation of zones of recirculation in the ascending aorta. In this computational model and within the range of anatomic parameters considered, the percentage of particles entering the cerebral vessels from a VAD-OG is reduced by nearly 60% by optimizing outflow-graft configuration. Ascending aorta recirculation zones, which may be thrombogenic, can also be eliminated. CFD methods coupled with patient-specific anatomy may aid in identifying the optimal location and angle for VAD-OG anastomosis to minimize stroke risk.
Journal Title
Journal of Biomechanical Engineering-Transactions of the Asme
Volume
136
Issue/Number
7
Publication Date
1-1-2014
Document Type
Article
DOI Link
Language
English
First Page
8
WOS Identifier
ISSN
0148-0731
Recommended Citation
"Mathematical Modeling of Patient-Specific Ventricular Assist Device Implantation to Reduce Particulate Embolization Rate to Cerebral Vessels" (2014). Faculty Bibliography 2010s. 4999.
https://stars.library.ucf.edu/facultybib2010/4999
Comments
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