Title

The Biogenesis of Chylomicrons

Authors

Authors

C. M. Mansbach;S. A. Siddiqi

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Annu. Rev. Physiol.

Keywords

lipid absorption; transport vesicles; chylomicrons; complex lipid; synthesis; FATTY-ACID-BINDING; TRIGLYCERIDE TRANSFER PROTEIN; RAT SMALL-INTESTINE; PRECHYLOMICRON TRANSPORT VESICLE; MAMMALIAN ENDOPLASMIC-RETICULUM; BIOSYNTHETIC CARGO SELECTION; B-CONTAINING LIPOPROTEINS; COMPLEX; LIPID-SYNTHESIS; APOLIPOPROTEIN-B; ACYL-COA; Physiology

Abstract

The absorption of dietary fat is of increasing concern given the rise of obesity not only in the United States but throughout the developed world. This review explores what happens to dietary fat within the enterocyte. Absorbed fatty acids and monoacylglycerols are required to be bound to intracellular proteins and/or to be rapidly converted to triacylglycerols to prevent cellular membrane disruption. The triacylglycerol produced at the level of the endoplasmic reticulum (ER) is either incorporated into prechylomicrons within the ER lumen or shunted to triacylglycerol storage pools. The prechylomicrons exit the ER in a specialized transport vesicle in the rate-limiting step in the intracellular transit of triacylglycerol across the enterocyte. The prechylomicrons are further processed in the Golgi and are transported to the basolateral membrane via a separate vesicular system for exocytosis into the intestinal lamina propria. Fatty acids and monoacylglycerols entering the enterocyte via the basolateral membrane are also incorporated into triacylglycerol, but the basolaterally entering lipid is much more likely to enter the triacylglycerol storage pool than the lipid entering via the apical membrane.

Journal Title

Annual Review of Physiology

Volume

72

Publication Date

1-1-2010

Document Type

Article

Language

English

First Page

315

Last Page

333

WOS Identifier

WOS:000276085100018

ISSN

0066-4278; 978-0-8243-0372-3

Share

COinS