Therapeutic potential of nanoceria in regenerative medicine

    Authors

    S. Das; S. Chigurupati; J. Dowding; P. Munusamy; D. R. Baer; J. F. McGinnis; M. P. Mattson; W. Self;S. Seal

    Comments

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    Abbreviated Journal Title

    MRS Bull.

    Keywords

    CERIUM OXIDE NANOPARTICLES; OXIDATIVE STRESS; CEO2 NANOPARTICLES; NEURONAL SURVIVAL; CELLS; RADIATION; PROTECT; MICE; NANOSTRUCTURES; PROLIFERATION; Materials Science, Multidisciplinary; Physics, Applied

    Abstract

    Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging, or trauma. Advancement of tissue engineering requires innovation in the field of three-dimensional scaffolding and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates that can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for an extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

    Journal Title

    Mrs Bulletin

    Volume

    39

    Issue/Number

    11

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    976

    Last Page

    983

    WOS Identifier

    WOS:000345121300017

    ISSN

    0883-7694

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