Nucleic Acid-Based Assays for the Detection of High-Risk Human Papillomavirus: A Technical Review

    Authors

    J. S. Gibson

    Comments

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    Abbreviated Journal Title

    Cancer Cytopathol.

    Keywords

    human papillomavirus; molecular tests; HPV nucleic acid testing; cervical cancer; THINPREP SPECIMENS; CERVICAL-CANCER; HPV; MANAGEMENT; TESTS; PERFORMANCE; GUIDELINES; Oncology; Pathology

    Abstract

    Nucleic acid-based high-risk human papillomavirus (hrHPV) testing is essential to contemporary cervical cancer screening. The numbers of commercially available assays approved by the US Food and Drug Administration for HPV nucleic acid detection have increased, each offering various approaches to analysis. An understanding of the methodologies associated with HPV testing is important to the practice of laboratory medicine. An overview of instruments, chemistries, laboratory workflows, and test limitations associated with current US Food and Drug Administration-approved assays is provided. (C) 2014 American Cancer Society.

    Journal Title

    Cancer Cytopathology

    Volume

    122

    Issue/Number

    9

    Publication Date

    1-1-2014

    Document Type

    Review

    Language

    English

    First Page

    639

    Last Page

    645

    WOS Identifier

    WOS:000342340300003

    ISSN

    1934-662X

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