Proteome-genome complexity as a metric of refractory disease

    Authors

    V. Gulati;R. Wallace

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    J. Proteomics

    Keywords

    Refractory disease; Proteomics; Genomics; Network medicine; Boolean; networks; Complexity; Biochemical Research Methods

    Abstract

    Treatment decisions for refractory diseases are frequently challenging because the benefits of disease-free survival and relief of symptoms must be balanced against the severity and frequency of side effects. A precise measure of disease resistance would therefore be valuable when assessing possible treatment strategies. In recent years there has been much interest in the modeling of proteomes and genomes as a means of identifying major pathways of disease causation. We suggest that these analyses may offer the additional benefit of quantifying refractory. (C) 2014 Elsevier B.V. All rights reserved.

    Journal Title

    Journal of Proteomics

    Volume

    110

    Publication Date

    1-1-2014

    Document Type

    Letter

    Language

    English

    First Page

    195

    Last Page

    197

    WOS Identifier

    WOS:000345183200016

    ISSN

    1874-3919

    Share

    COinS