Title

Proteome-genome complexity as a metric of refractory disease

Authors

Authors

V. Gulati;R. Wallace

Comments

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Abbreviated Journal Title

J. Proteomics

Keywords

Refractory disease; Proteomics; Genomics; Network medicine; Boolean; networks; Complexity; Biochemical Research Methods

Abstract

Treatment decisions for refractory diseases are frequently challenging because the benefits of disease-free survival and relief of symptoms must be balanced against the severity and frequency of side effects. A precise measure of disease resistance would therefore be valuable when assessing possible treatment strategies. In recent years there has been much interest in the modeling of proteomes and genomes as a means of identifying major pathways of disease causation. We suggest that these analyses may offer the additional benefit of quantifying refractory. (C) 2014 Elsevier B.V. All rights reserved.

Journal Title

Journal of Proteomics

Volume

110

Publication Date

1-1-2014

Document Type

Letter

Language

English

First Page

195

Last Page

197

WOS Identifier

WOS:000345183200016

ISSN

1874-3919

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