Title
Health-Related Quality of Life Over Time in Children With Eosinophilic Esophagitis and Their Families
Abbreviated Journal Title
J. Pediatr. Gastroenterol. Nutr.
Keywords
eosinophilic esophagitis; family impact; health-related quality of life; pediatric; GENERIC CORE SCALES; ELIMINATION DIET; GASTROINTESTINAL DISORDERS; CONSENSUS RECOMMENDATIONS; FLUTICASONE PROPIONATE; PARENTING STRESS; IMPACT MODULE; RELIABILITY; VALIDITY; PEDSQL(TM)-4.0; Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
Abstract
Objectives: Existing treatments for pediatric eosinophilic esophagitis (EoE) effectively reduce inflammation. The impact of treatment on health-related quality of life (HRQoL) over time for pediatric patients with EoE and their families, however, has not been systematically assessed. We hypothesized that individualized multidisciplinary treatment would improve both child and family HRQoL over time, with improvements associated with decreased symptom severity. Methods: Children with EoE treated in 4 tertiary care centers were enrolled. Baseline assessments occurred at the time of patients' first evaluation; follow-up assessments occurred at 2 and 6 months after baseline. Presence and severity of 8 EoE symptoms were measured. HRQoL was measured with the Pediatric Quality of Life Inventory parent proxy report, child self-report (CR), and Family Impact Module (FIM). Statistical analyses used mixed-effects modeling to test changes over time for child and family HRQoL. Results: Ninety-seven children were enrolled (ages 2-18 years, mean age 7.7 years +/- 4.8, 78% boys, 80% white). Baseline mean symptom number was 3.5 (standard deviation 2.3), and symptom severity was 5.5 (standard deviation, 4.5). HRQoL scores were significantly related to symptom scores (P < 0.001). EoE symptom severity decreased during the study (P = 0.03). Pediatric Quality of Life Inventory parent proxy Total and FIM Total scores improved from baseline to 6 months (respectively, adjusted means 78.4 vs 81.0, P = 0.0006; 68.9 vs 70.1, P = 0.03). Interactions with baseline symptom severity revealed that subjects with lowest symptom severity showed the most improved HRQoL scores (P = 0.0013). Conclusions: HRQoL improved during the course of evaluation and treatment, with positive changes being strongest for patients with less symptom severity at baseline.
Journal Title
Journal of Pediatric Gastroenterology and Nutrition
Volume
59
Issue/Number
3
Publication Date
1-1-2014
Document Type
Article
Language
English
First Page
308
Last Page
316
WOS Identifier
ISSN
0277-2116
Recommended Citation
"Health-Related Quality of Life Over Time in Children With Eosinophilic Esophagitis and Their Families" (2014). Faculty Bibliography 2010s. 5578.
https://stars.library.ucf.edu/facultybib2010/5578
Comments
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