Influence of HMB Supplementation and Resistance Training on Cytokine Responses to Resistance Exercise

    Authors

    W. J. Kraemer; D. L. Hatfield; B. A. Comstock; M. S. Fragala; P. M. Davitt; C. Cortis; J. M. Wilson; E. C. Lee; R. U. Newton; C. Dunn-Lewis; K. Hakkinen; T. K. Szivak; D. R. Hooper; S. D. Flanagan; D. P. Looney; M. T. White; J. S. Volek;C. M. Maresh

    Comments

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    Abbreviated Journal Title

    J. Am. Coll. Nutr.

    Keywords

    myokine; muscle damage; immune function; nutrition; strength training; HYDROXY-BETA-METHYLBUTYRATE; TUMOR-NECROSIS-FACTOR; CHAIN AMINO-ACIDS; ECCENTRIC EXERCISE; SKELETAL-MUSCLE; INFLAMMATORY RESPONSE; CARBOHYDRATE; INGESTION; PROTEIN-DEGRADATION; CELL-PROLIFERATION; OXIDATIVE DAMAGE; Nutrition & Dietetics

    Abstract

    Purpose: The purpose of this study was to determine the effects of a multinutritional supplement including amino acids, -hydroxy--methylbutyrate (HMB), and carbohydrates on cytokine responses to resistance exercise and training.Methods: Seventeen healthy, college-aged men were randomly assigned to a Muscle Armor (MA; Abbott Nutrition, Columbus, OH) or placebo supplement group and 12 weeks of resistance training. An acute resistance exercise protocol was administered at 0, 6, and 12 weeks of training. Venous blood samples at pre-, immediately post-, and 30-minutes postexercise were analyzed via bead multiplex immunoassay for 17 cytokines.Results: After 12 weeks of training, the MA group exhibited decreased interferon-gamma (IFN-) and interleukin (IL)-10. IL-1 differed by group at various times. Granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-7, IL-8, IL-12p70, IL-13, IL-17, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1) changed over the 12-week training period but did not differ by group.Conclusions: Twelve weeks of resistance training alters the cytokine response to acute resistance exercise, and supplementation with HMB and amino acids appears to further augment this result.

    Journal Title

    Journal of the American College of Nutrition

    Volume

    33

    Issue/Number

    4

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    247

    Last Page

    255

    WOS Identifier

    WOS:000342139900001

    ISSN

    0731-5724

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