Hyperleptinemia is Associated With CRP but Not Apolipoprotein E and is Reduced by Exercise Training

    Authors

    J. Lowndes; R. F. Zoeller; G. A. Kyriazis; M. P. Miles; R. L. Seip; N. M. Moyna; P. S. Visich; L. S. Pescatello; P. M. Gordon; P. D. Thompson;T. J. Angelopoulos

    Comments

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    Abbreviated Journal Title

    Int. J. Sport Nutr. Exerc. Metab.

    Keywords

    exercise physiology; metabolism; gender; endurance training; C-REACTIVE PROTEIN; INDUCED LEPTIN RESISTANCE; PREDICTING BODY DENSITY; E POLYMORPHISM; GENERALIZED EQUATIONS; OBESE HUMANS; WEIGHT-LOSS; E; GENOTYPE; MEN; ATHEROSCLEROSIS; Nutrition & Dietetics; Sport Sciences

    Abstract

    The purpose of this study was to examine whether leptin levels affect the response of leptin to exercise training (ET) and whether this is also affected by C-reactive protein (CRP) or the three common Apolipoprotein E genotypes (APOE). Ninety-seven (male = 45, female = 52) sedentary individuals underwent 6 months of supervised ET. Blood was sampled before the initiation of ET, and again 24 and 72 hr after completion of the final training session. ET resulted in a small reduction in body mass (80.47 +/- 18.03 vs 79.42 +/- 17.34 kg, p < .01). Leptin was reduced 24 hr after the final exercise session (p < .01), but returned to normal after 72 hr (p > .05)-Pre: 13.51 +/- 12.27, 24hr: 12.14 +/- 12.34, 72hr: 12.98 +/- 11.40 ng/ml. The most hyperleptinemic individuals had a greater initial response, which was sustained through to 72 hr after the final session in the pooled study population (p < .01), and in both males (p < .05) and females (p < .05) separately. CRP was related to leptin independently of body weight and positively related to the reductions in leptin. APOE genotype was not related to leptin levels and did not affect the response to ET. Leptin levels may only be reduced by ET in those with hyperleptinemia. In addition, both the initial extent of hyperleptinemia and the subsequent reduction in leptin may be related to low grade chronic systemic inflammation.

    Journal Title

    International Journal of Sport Nutrition and Exercise Metabolism

    Volume

    24

    Issue/Number

    5

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    524

    Last Page

    531

    WOS Identifier

    WOS:000343640800005

    ISSN

    1526-484X

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