Title

Successful gestation and delivery using clopidogrel for secondary stroke prophylaxis: a case report and literature review

Authors

Authors

C. R. Reilly; A. Cuesta-Fernandez;O. R. Kayaleh

Comments

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Abbreviated Journal Title

Arch. Gynecol. Obstet.

Keywords

Clopidogrel; Pregnancy; Stroke prevention; Thienopyridine; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY; PREGNANCY; Obstetrics & Gynecology

Abstract

Literature is scarce regarding the use of clopidogrel during pregnancy and the potential hazard to maternal and fetal health. We report a 33-year-old female, who presented to our clinic at 40 weeks gestation with a history of multiple prior ischemic strokes and transient ischemic attacks. The patient was placed on clopidogrel for secondary stroke prophylaxis prior to conception and maintained therapy throughout pregnancy without interruption or complication. Clopidogrel was discontinued 7 days prior to induction of labor, and a healthy baby was vaginally delivered without bleeding complications or congenital anomalies. Clopidogrel was restarted 12 hours postpartum without an incident. To our knowledge, this is the first report of clopidogrel use in pregnancy for secondary stroke prophylaxis. We also provide a current review of the literature of the use of clopidogrel in pregnancy. Based on the limited data available, clopidogrel use in pregnancy has not demonstrated significant toxicity to either the mother or the newborn. However, additional studies are needed to further assess the efficacy and safety of this medication in this patient population.

Journal Title

Archives of Gynecology and Obstetrics

Volume

290

Issue/Number

3

Publication Date

1-1-2014

Document Type

Review

Language

English

First Page

591

Last Page

594

WOS Identifier

WOS:000340518300032

ISSN

0932-0067

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