SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

    Authors

    C. Sprouse; H. Gordish-Dressman; E. F. Orkunoglu-Suer; J. S. Lipof; S. Moeckel-Cole; R. R. Patel; K. Adham; J. S. Larkin; M. J. Hubal; A. K. Kearns; P. M. Clarkson; P. D. Thompson; T. J. Angelopoulos; P. M. Gordon; N. M. Moyna; L. S. Pescatello; P. S. Visich; R. F. Zoeller; E. P. Hoffman; L. L. Tosi;J. M. Devaney

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Diabetes

    Keywords

    GENOME-WIDE ASSOCIATION; RANDOMIZED CONTROLLED-TRIAL; RISK LOCI; ZINC; TRANSPORTER; POLYMORPHISMS; TCF7L2; CDKAL1; DAMAGE; ZNT-8; Endocrinology & Metabolism

    Abstract

    Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adultsthe Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training.

    Journal Title

    Diabetes

    Volume

    63

    Issue/Number

    1

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    363

    Last Page

    368

    WOS Identifier

    WOS:000328680400042

    ISSN

    0012-1797

    Share

    COinS