Title

Deoxyribonucleoside-Modified Squaraines as Near-IR Viscosity Sensors

Authors

Authors

Y. W. Zhang; X. Yue; B. Kim; S. Yao;K. D. Belfield

Comments

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Abbreviated Journal Title

Chem.-Eur. J.

Keywords

aggregation; deoxyribonucleosides; near-IR imaging; squaraine dyes; viscosity sensors; LANGMUIR-BLODGETT-FILMS; LIVE CELLS; VISCOELASTIC PROPERTIES; 2-PHOTON; ABSORPTION; CELLULAR-VISCOSITY; SERUM-ALBUMIN; AGGREGATION; DYE; DNA; MICROTUBULES; Chemistry, Multidisciplinary

Abstract

Deoxyribonucleoside-modified squaraines were synthesized by Sonogashira coupling reactions using an unsymmetrical, terminal alkynylated benzothiazolium squaraine dye. These non-natural nucleosides exhibited fluorescent 'turn-on' properties in viscous conditions with an enhancement of > 300-fold. The viscosity-dependent fluorescence enhancement was attributed to a combination of hampering both molecular aggregation and intramolecular bond rotation of the squaraine probe. Fluorescence microscopy allowed visualization of highly viscous regions during various stages of cellular mitosis.

Journal Title

Chemistry-a European Journal

Volume

20

Issue/Number

24

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

7249

Last Page

7253

WOS Identifier

WOS:000337617500009

ISSN

0947-6539

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