Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma

    Authors

    X. Zhi; K. Lamperska; P. Golusinski; N. J. Schork; L. Luczewski; W. Golusinski;M. M. Masternak

    Comments

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    Abbreviated Journal Title

    Growth Horm. IGF Res.

    Keywords

    Oral cancer; IGF1; IGF2; Survival; ORAL-CANCER; FACTOR-I; BINDING PROTEIN-3; PROSTATE-CANCER; UP-REGULATION; RISK; ALCOHOL; TOBACCO; Cell Biology; Endocrinology & Metabolism

    Abstract

    Insulin-like growth factors (IGF) 1 and 2 are known as potential mitogens for normal and neoplastic cells. IGF2 is a main fetal growth factor while IGF1 is activated through growth hormone action during postnatal growth and development. However, there is strong evidence that activation of IGF2 by its E2F transcription factor 3 (E2F3) is present in different types of cancer. Also high levels of IGF1 strongly correlate with cancer development due to anti-apoptotic properties and enhancement of cancer cell differentiation, which can be attenuated by IGFBP3. Head and neck cancer is known as one of the six most common human cancers. The main risk factor for head and neck cancer is consumption of tobacco and alcohol as well as viral infection and bacterial infection by stimulation of chronic local inflammation. There is also a genetic basis for this form of cancer; however, the genetic markers are not yet established. In this study we investigated the levels of the expression of IGF2, IGF1, E2F3 and IGFBP3 in human cancers and healthy tissues surrounding the tumor obtained from each of 41 patients. Our study indicated that there is no alteration of the levels of expression of IGF2, E2F3 and IGF1 in head and neck squamous cell carcinoma (HNSCC) cases studied in selected experimental population, but there was evidence for upregulation of pro-apoptotic IGFBP3 in cancer when comparing to healthy tissue. These important findings indicate that insulin-growth factors are not directly associated with HNSCC showing some variability between patients and location of tumor. However, elevated level of IGFBP3 suggests possible regulatory role of IGF signal by its binding protein in this type of tumor. (C) 2014 Elsevier Ltd. All rights reserved.

    Journal Title

    Growth Hormone & Igf Research

    Volume

    24

    Issue/Number

    4

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    137

    Last Page

    141

    WOS Identifier

    WOS:000339701900006

    ISSN

    1096-6374

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