Fructose Containing Sugars Do Not Raise Blood Pressure or Uric Acid at Normal Levels of Human Consumption

    Authors

    T. J. Angelopoulos; J. Lowndes; S. Sinnett;J. M. Rippe

    Comments

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    Abbreviated Journal Title

    J. Clin. Hypertens.

    Keywords

    CARDIOMETABOLIC RISK-FACTORS; METABOLIC SYNDROME; ESSENTIAL-HYPERTENSION; INCIDENT HYPERTENSION; DIETARY FRUCTOSE; KIDNEY-DISEASE; GLOBAL BURDEN; CORN SYRUP; RATS; HYPERURICEMIA; Peripheral Vascular Disease

    Abstract

    The impact of fructose, commonly consumed with sugars by humans, on blood pressure and uric acid has yet to be defined. A total of 267 weight-stable participants drank sugar-sweetened milk every day for 10weeks as part of their usual, mixed-nutrient diet. Groups 1 and 2 had 9% estimated caloric intake from fructose or glucose, respectively, added to milk. Groups 3 and 4 had 18% of estimated caloric intake from high fructose corn syrup or sucrose, respectively, added to the milk. Blood pressure and uric acid were determined prior to and after the 10-week intervention. There was no effect of sugar type on either blood pressure or uric acid (interaction P > .05), and a significant time effect for blood pressure was noted (P < .05). The authors conclude that 10weeks of consumption of fructose at the 50th percentile level, whether consumed as pure fructose or with fructose-glucose-containing sugars, does not promote hyperuricemia or increase blood pressure. (C) 2014 Wiley Periodicals, Inc.

    Journal Title

    Journal of Clinical Hypertension

    Volume

    17

    Issue/Number

    2

    Publication Date

    1-1-2015

    Document Type

    Article

    Language

    English

    First Page

    87

    Last Page

    94

    WOS Identifier

    WOS:000349621300002

    ISSN

    1524-6175

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