MCP-induced protein 1 suppresses TNF alpha-induced VCAM-1 expression in human endothelial cells

    Authors

    Y. F. Qi; J. A. Liang; Z. G. She; Y. Cai; J. Wang; T. H. Lei; W. B. Stallcup;M. G. Fu

    Comments

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    Abbreviated Journal Title

    FEBS Lett.

    Keywords

    MCPIP1; Endothelial cell; Inflammation; NF-kappa B signaling; Adhesion; molecule; MONOCYTE CHEMOATTRACTANT PROTEIN-1; KAPPA-B; PROINFLAMMATORY ACTIVATION; TRANSCRIPTION FACTOR; MESSENGER-RNA; ATHEROSCLEROSIS; REGULATOR; REVEALS; MICE; Biochemistry & Molecular Biology; Biophysics; Cell Biology

    Abstract

    Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We here report that treatment of human umbilical vein endothelial cells (HUVECs) with tumor necrosis factor (TNF) alpha substantially increased the expression of MCP-induced protein 1 (MCPIP1). Overexpression of MCPIP1 protected ECs against TNF alpha-induced endothelial activation, as characterized by the attenuation in the expression of the adhesion molecule VCAM-1 and monocyte adherence to ECs. Conversely, small interfering RNA-mediated knock down of MCPIP1 increased the expression of VCAM-1 and monocytic adherence to ECs. These studies identified MCPIP1 as a feedback control of cytokines-induced endothelial inflammation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    Journal Title

    Febs Letters

    Volume

    584

    Issue/Number

    14

    Publication Date

    1-1-2010

    Document Type

    Article

    Language

    English

    First Page

    3065

    Last Page

    3072

    WOS Identifier

    WOS:000279438800017

    ISSN

    0014-5793

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