Title

MCP-induced protein 1 suppresses TNF alpha-induced VCAM-1 expression in human endothelial cells

Authors

Authors

Y. F. Qi; J. A. Liang; Z. G. She; Y. Cai; J. Wang; T. H. Lei; W. B. Stallcup;M. G. Fu

Comments

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Abbreviated Journal Title

FEBS Lett.

Keywords

MCPIP1; Endothelial cell; Inflammation; NF-kappa B signaling; Adhesion; molecule; MONOCYTE CHEMOATTRACTANT PROTEIN-1; KAPPA-B; PROINFLAMMATORY ACTIVATION; TRANSCRIPTION FACTOR; MESSENGER-RNA; ATHEROSCLEROSIS; REGULATOR; REVEALS; MICE; Biochemistry & Molecular Biology; Biophysics; Cell Biology

Abstract

Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We here report that treatment of human umbilical vein endothelial cells (HUVECs) with tumor necrosis factor (TNF) alpha substantially increased the expression of MCP-induced protein 1 (MCPIP1). Overexpression of MCPIP1 protected ECs against TNF alpha-induced endothelial activation, as characterized by the attenuation in the expression of the adhesion molecule VCAM-1 and monocyte adherence to ECs. Conversely, small interfering RNA-mediated knock down of MCPIP1 increased the expression of VCAM-1 and monocytic adherence to ECs. These studies identified MCPIP1 as a feedback control of cytokines-induced endothelial inflammation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Journal Title

Febs Letters

Volume

584

Issue/Number

14

Publication Date

1-1-2010

Document Type

Article

Language

English

First Page

3065

Last Page

3072

WOS Identifier

WOS:000279438800017

ISSN

0014-5793

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