Title

Nuclease-containing media for resettable operation of DNA logic gates

Authors

Authors

M. R. O'Steen; E. M. Cornett;D. M. Kolpashchikov

Comments

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Abbreviated Journal Title

Chem. Commun.

Keywords

POLYNUCLEOTIDE KINASE-ACTIVITY; STRAND-DISPLACEMENT; SENSITIVE; DETECTION; G-QUADRUPLEX; SYSTEMS; PROBE; NANOTECHNOLOGY; DEOXYRIBOZYME; AMPLIFICATION; QUENCHER; Chemistry, Multidisciplinary

Abstract

We designed and tested a system that allows DNA logic gates to respond multiple times to the addition of oligonucleotide inputs. After producing an output signal, the system spontaneously resets to the background state. This system does not require any operator action to achieve reset of a DNA logic gate, and may become useful for construction of reusable DNA-based computational devices.

Journal Title

Chemical Communications

Volume

51

Issue/Number

8

Publication Date

1-1-2015

Document Type

Article

Language

English

First Page

1429

Last Page

1431

WOS Identifier

WOS:000347232200007

ISSN

1359-7345

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