Nuclease-containing media for resettable operation of DNA logic gates

    Authors

    M. R. O'Steen; E. M. Cornett;D. M. Kolpashchikov

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Chem. Commun.

    Keywords

    POLYNUCLEOTIDE KINASE-ACTIVITY; STRAND-DISPLACEMENT; SENSITIVE; DETECTION; G-QUADRUPLEX; SYSTEMS; PROBE; NANOTECHNOLOGY; DEOXYRIBOZYME; AMPLIFICATION; QUENCHER; Chemistry, Multidisciplinary

    Abstract

    We designed and tested a system that allows DNA logic gates to respond multiple times to the addition of oligonucleotide inputs. After producing an output signal, the system spontaneously resets to the background state. This system does not require any operator action to achieve reset of a DNA logic gate, and may become useful for construction of reusable DNA-based computational devices.

    Journal Title

    Chemical Communications

    Volume

    51

    Issue/Number

    8

    Publication Date

    1-1-2015

    Document Type

    Article

    Language

    English

    First Page

    1429

    Last Page

    1431

    WOS Identifier

    WOS:000347232200007

    ISSN

    1359-7345

    Share

    COinS