Catalytic properties and biomedical applications of cerium oxide nanoparticles

    Authors

    C. Walkey; S. Das; S. Seal; J. Erlichman; K. Heckman; L. Ghibelli; E. Traversa; J. F. McGinnis;W. T. Self

    Comments

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    Abbreviated Journal Title

    Environ.-Sci. Nano

    Keywords

    BRAIN-SLICE MODEL; PROTEIN CORONA; OXIDATIVE STRESS; CELLULAR UPTAKE; ANTIOXIDANT PROPERTIES; ENDOTHELIAL-CELLS; INTRAVITREAL INJECTION; DIOXIDE NANOPARTICLES; CEO2 NANOPARTICLES; BIOLOGICAL-SYSTEMS; Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience &; Nanotechnology

    Abstract

    Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials?

    Journal Title

    Environmental Science-Nano

    Volume

    2

    Issue/Number

    1

    Publication Date

    1-1-2015

    Document Type

    Review

    Language

    English

    First Page

    33

    Last Page

    53

    WOS Identifier

    WOS:000349222200005

    ISSN

    2051-8153

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