Compromised respiratory adaptation and thermoregulation in aging and age-related diseases

    Authors

    S. L. Chan; Z. L. Wei; S. Chigurupati;W. H. Tu

    Comments

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    Abbreviated Journal Title

    Ageing Res. Rev.

    Keywords

    Respiration; Uncoupling proteins; Reactive oxygen species; Mitochondria; Aging; Neurodegeneration; Energy metabolism; MITOCHONDRIAL UNCOUPLING PROTEINS; AMYOTROPHIC-LATERAL-SCLEROSIS; OXYGEN; SPECIES PRODUCTION; SKELETAL-MUSCLE MITOCHONDRIA; BROWN-ADIPOSE-TISSUE; HYDROGEN-PEROXIDE PRODUCTION; CENTRAL-NERVOUS-SYSTEM; BETA-CELL; DYSFUNCTION; AFFECTS ENERGY-METABOLISM; TERM CALORIE RESTRICTION; Cell Biology; Geriatrics & Gerontology

    Abstract

    Mitochondrial dysfunction and reactive oxygen species (ROS) production are at the heart of the aging process and are thought to underpin age-related diseases. Mitochondria are not only the primary energy-generating system but also the dominant cellular source of metabolically derived ROS. Recent studies unravel the existence of mechanisms that serve to modulate the balance between energy metabolism and RIDS production. Among these is the regulation of proton conductance across the inner mitochondrial membrane that affects the efficiency of respiration and heat production. The field of mitochondrial respiration research has provided important insight into the role of altered energy balance in obesity and diabetes. The notion that respiration and oxidative capacity are mechanistically linked is making significant headway into the field of aging and age-related diseases. Here we review the regulation of cellular energy and ROS balance in biological systems and survey some of the recent relevant studies that suggest that respiratory adaptation and thermodynamics are important in aging and age-related diseases. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

    Journal Title

    Ageing Research Reviews

    Volume

    9

    Issue/Number

    1

    Publication Date

    1-1-2010

    Document Type

    Review

    Language

    English

    First Page

    20

    Last Page

    40

    WOS Identifier

    WOS:000274616100003

    ISSN

    1568-1637

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