Aliphatic Hyperbranched Polyester: A New Building Block in the Construction of Multifunctional Nanoparticles and Nanocomposites

    Authors

    S. Santra; C. Kaittanis;J. M. Perez

    Comments

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    Abbreviated Journal Title

    Langmuir

    Keywords

    OXIDE NANOPARTICLES; CLICK CHEMISTRY; CANCER-THERAPY; POLYMER; CELLS; PACLITAXEL; IDENTIFICATION; ENCAPSULATION; MICROSPHERES; THERAPEUTICS; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, ; Multidisciplinary

    Abstract

    Herein we report the design and synthesis of multifunctional hyperbranched polyester-based nanoparticles and nanocomposites with properties ranging from magnetic, fluorescence, antioxidant and X-ray contrast. The fabrication of these nanostructures was achieved using a novel aliphatic and biodegradable hyperbranched polyester (HBPE) synthesized from readily available diethyl malonate. The polymer's globular structure with functional surface carboxylic groups and hydrophobic cavities residing in the polymer's interior allows for the formation of multifunctional polymeric nanoparticles, which are able to encapsulate a diversity of hydrophobic cargos. Via simple surface chemistry modifications, the surface carboxylic acid groups were modified to yield nanoparticles with a variety of surface functionalizations, such as amino. azide and propargyl groups, which mediated the conjugation of small molecules. This capability achieved the engineering of the HBPE nanoparticle surface for specific cell internalization studies and the formation of nanoparticle assemblies for the creation of novel nanocomposites that retained, and in some cases enhanced, the properties of the parental nanoparticle building blocks. Considering these results, the HIVE polymer, nanoparticles and composites should be ideal for biomedical, phrmaceutical, nanophotonics applications.

    Journal Title

    Langmuir

    Volume

    26

    Issue/Number

    8

    Publication Date

    1-1-2010

    Document Type

    Article

    Language

    English

    First Page

    5364

    Last Page

    5373

    WOS Identifier

    WOS:000276562300014

    ISSN

    0743-7463

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