Title
Aliphatic Hyperbranched Polyester: A New Building Block in the Construction of Multifunctional Nanoparticles and Nanocomposites
Abbreviated Journal Title
Langmuir
Keywords
OXIDE NANOPARTICLES; CLICK CHEMISTRY; CANCER-THERAPY; POLYMER; CELLS; PACLITAXEL; IDENTIFICATION; ENCAPSULATION; MICROSPHERES; THERAPEUTICS; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, ; Multidisciplinary
Abstract
Herein we report the design and synthesis of multifunctional hyperbranched polyester-based nanoparticles and nanocomposites with properties ranging from magnetic, fluorescence, antioxidant and X-ray contrast. The fabrication of these nanostructures was achieved using a novel aliphatic and biodegradable hyperbranched polyester (HBPE) synthesized from readily available diethyl malonate. The polymer's globular structure with functional surface carboxylic groups and hydrophobic cavities residing in the polymer's interior allows for the formation of multifunctional polymeric nanoparticles, which are able to encapsulate a diversity of hydrophobic cargos. Via simple surface chemistry modifications, the surface carboxylic acid groups were modified to yield nanoparticles with a variety of surface functionalizations, such as amino. azide and propargyl groups, which mediated the conjugation of small molecules. This capability achieved the engineering of the HBPE nanoparticle surface for specific cell internalization studies and the formation of nanoparticle assemblies for the creation of novel nanocomposites that retained, and in some cases enhanced, the properties of the parental nanoparticle building blocks. Considering these results, the HIVE polymer, nanoparticles and composites should be ideal for biomedical, phrmaceutical, nanophotonics applications.
Journal Title
Langmuir
Volume
26
Issue/Number
8
Publication Date
1-1-2010
Document Type
Article
DOI Link
Language
English
First Page
5364
Last Page
5373
WOS Identifier
ISSN
0743-7463
Recommended Citation
"Aliphatic Hyperbranched Polyester: A New Building Block in the Construction of Multifunctional Nanoparticles and Nanocomposites" (2010). Faculty Bibliography 2010s. 737.
https://stars.library.ucf.edu/facultybib2010/737
Comments
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