Title
Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue
Abbreviated Journal Title
Mol. Cell. Endocrinol.
Keywords
Hypothermia; Epinephrine; Knockout; Thermogenesis; Brown adipose tissue; TARGETED DISRUPTION; RECEPTOR GENE; MICE LACKING; ADAPTIVE; THERMOGENESIS; OBESITY; SYSTEM; Cell Biology; Endocrinology & Metabolism
Abstract
Catecholamines are involved in thermogenesis. We investigated the specific role of epinephrine in regulation of temperature homeostasis in mice. We subjected adult wildtype (WT) and phenylethanolamine N-methyl transferase knock out mice (Pnmt(-/-)) lacking epinephrine to cold for 24h. Body temperature and thyroid hormone levels were not different between WT and Pnmt(-/-) mice. Although temperature was normal in Pnmt(-/-) mice, the brown fat response to cold was abnormal with no increase in Ucp-1 or Pgc-1 alpha mRNA levels (but with an exaggerated cold-induced lipid loss from the tissue). Our results show that epinephrine may have a role in brown fat mitochondrial uncoupling through regulation of Ucp-1 and Pgc-1 alpha, although this is not required to maintain a normal temperature during acute cold exposure. We conclude that epinephrine may have an important role in induction of Ucp-1 and Pgc-1 alpha gene expression during cold stress. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Journal Title
Molecular and Cellular Endocrinology
Volume
328
Issue/Number
1-2
Publication Date
1-1-2010
Document Type
Article
Language
English
First Page
34
Last Page
39
WOS Identifier
ISSN
0303-7207
Recommended Citation
"Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue" (2010). Faculty Bibliography 2010s. 770.
https://stars.library.ucf.edu/facultybib2010/770
Comments
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