Title
Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice
Abbreviated Journal Title
Pharmacogn. Mag.
Keywords
D-galactosamine; Limonium sinense (Girard) Ktze; lipopolysaccharide; mitochondrial Ca(2+)-ATPase activity; mitochondrial Ca(2+) overload; PERMEABILITY TRANSITION; CARBON-TETRACHLORIDE; INJURY; ACID; HEPATOPROTECTION; INTOXICATION; INHIBITION; MECHANISMS; APOPTOSIS; CULTURE; Chemistry, Medicinal
Abstract
Mechanisms underlying the mitochondrial protection of Limonium sinense extracts (LSE) was studied in lipopolysaccharide and D-galactosamine (LPS/D-GalN) intoxicated mice. It was found that increased activities of serum aspartate aminotransferase and alanine aminotransferase induced by LPS/D-GalN were significantly inhibited by pretreatment with LSE. The obvious disruption of membrane potential, intramitochondrial Ca(2+) overload and suppression in mitochondrial Ca(2+)-ATPase activity induced by LPS/D-GalN were significantly blocked by pretreatment with LSE. It was concluded that mechanisms underlying protection of LSE against liver mitochondria damage might be related to the preservation on mitochondrial Ca(2+) homeostasis through the preservation on mitochondrial Ca(2+)-ATPase activity.
Journal Title
Pharmacognosy Magazine
Volume
6
Issue/Number
23
Publication Date
1-1-2010
Document Type
Article
Language
English
First Page
191
Last Page
197
WOS Identifier
ISSN
0973-1296
Recommended Citation
"Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice" (2010). Faculty Bibliography 2010s. 855.
https://stars.library.ucf.edu/facultybib2010/855
Comments
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