Nanobioimaging and sensing of infectious diseases

    Authors

    P. Tanury; A. Malhotra; L. M. Byrne;S. Santra

    Comments

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    Abbreviated Journal Title

    Adv. Drug Deliv. Rev.

    Keywords

    Fluorescent nanoparticles; Multiplexing; Viral imaging; Bacterial; detection; Surface plasmon resonance; Colorimetric assay; Magnetic; nanosensors; Immunomagnetic separation; BIOFUNCTIONAL MAGNETIC NANOPARTICLES; SYNCYTIAL VIRUS-INFECTION; ESCHERICHIA-COLI O157/H7; GRAM-NEGATIVE BACTERIA; QUANTUM-DOT PROBES; IMMUNOMAGNETIC SEPARATION; SILICA NANOPARTICLES; GOLD NANOPARTICLES; PATHOGEN DETECTION; RAPID DETECTION; Pharmacology & Pharmacy

    Abstract

    New methods to identify trace amount of infectious pathogens rapidly, accurately and with high sensitivity are in constant demand to prevent epidemics and loss of lives. Early detection of these pathogens to prevent, treat and contain the spread of infections is crucial. Therefore, there is a need and urgency for sensitive, specific, accurate, easy-to-use diagnostic tests. Versatile biofunctionalized engineered nanomaterials are proving to be promising in meeting these needs in diagnosing the pathogens in food, blood and clinical samples. The unique optical and magnetic properties of the nanoscale materials have been put to use for the diagnostics. In this review, we focus on the developments of the fluorescent nanoparticles, metallic nanostructures and superparamagnetic nanoparticles for bioimaging and detection of infectious microorganisms. The various nanodiagnostic assays developed to image, detect and capture infectious virus and bacteria in solutions, food or biological samples in vitro and in vivo are presented and their relevance to developing countries is discussed. (C) 2009 Elsevier B.V. All rights reserved.

    Journal Title

    Advanced Drug Delivery Reviews

    Volume

    62

    Issue/Number

    4-5

    Publication Date

    1-1-2010

    Document Type

    Review

    Language

    English

    First Page

    424

    Last Page

    437

    WOS Identifier

    WOS:000276123400005

    ISSN

    0169-409X

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