In this study, a Monte Carlo simulation was designed to observe the self-assembly of the HIV-1 capsid protein. The simulation allowed a coarse grained model of the capsid protein with defined interaction sites to move freely in three dimensions using the Metropolis criterion. Observations were made as to which parameters affected the assembly the process. The ways in which the assembly were affected were also noted. It was found that proper dimerization of the capsid protein was necessary in order for the lattice to form properly. It was also found that a strong trimeric interface could be responsible for double-layered assemblies. Further studies may be conducted by further varying of parameters or reworking the dynamics of the simulation. The possible causes of curvature within the assembly still need to be researched further.
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Bachelor of Science (B.S.)
College of Sciences
Dissertations, Academic -- Sciences; Sciences -- Dissertations, Academic
Length of Campus-only Access
Honors in the Major Thesis
Weber, Jeffrey, "Coarse Grained Monte Carlo Simulation of the Self-Assembly of the HIV-1 Capsid Protein" (2014). HIM 1990-2015. 1627.