Abstract
A new in vitro culture model for latency of tuberculosis pathogen suitable for screening chemical libraries was developed by subjecting the pathogen to multiple stresses that the pathogen is thought to encounter in the host. When subjected to these stress factors, the pathogen develops key features characteristic of latency, drug resistance and lipid storage. Using the culture, a method to screen chemicals was developed. This method is suitable for high through put screening.
Document Type
Patent
Patent Number
US 8,012,492
Application Serial Number
12/107,146
Issue Date
9-6-2011
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
Burnett School of Biomedical Sciences
Department
Biomolecular Science Center
Allowance Date
5-23-2011
Filing Date
4-22-2008
Assignee at Filing
UCFRF
Filing Type
Nonprovisional Application Record
Donated
no
Recommended Citation
Kolattukudy, Pappachan; Daniel, Jaiyanth; Deb, Chirajyoti; and Sirakova, Tatiana, "In Vitro Model of Latent Mycobacterial Infection" (2011). UCF Patents. 264.
https://stars.library.ucf.edu/patents/264