Abstract
So far research has been focused almost exclusively on searching "individual" proteins as protein biomarkers for cancer detection and diagnosis. The level change of an individual protein target in biological systems and fluids is most commonly studied to identify their potential association with cancer. Using a nanoparticle aggregation immunoassay, we discovered several proteins that are substantially more complexed/aggregated in different cancer than normal tissue. The level of protein complex/aggregate in a biological system can serve as a biomarker for disease detection and as a target of therapy. In one particular example, prostate cancer is clearly distinguishable from normal prostate and prostate with benign conditions according to the complex/aggregate level of a unique biomarker protein.
Document Type
Patent
Patent Number
US 9,005,994
Application Serial Number
13/522,391
Issue Date
4-14-2015
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
NanoScience Technology Center
Department
NanoScience Technology Center
Allowance Date
12-15-2014
Filing Date
7-6-2012
Assignee at Filing
UCFRF
Filing Type
National Filing Record
Donated
no
Recommended Citation
Huo, Qun, "Methods for biomolecule and biomolecule complex (bmc) detection and analysis and the use of such for research and medical diagnosis (US)" (2015). UCF Patents. 374.
https://stars.library.ucf.edu/patents/374