Abstract

A novel class of methyl esters of substituted 4-oxo-2-butenoic acids and their derivatives are disclosed along with the surprising use property of these compounds as a bacteriostatic agents for humans or non-humans against mycobacteria. These compounds include: 4-(4-Ethoxy-phenyl)-2-(N-fluoren-9-ylidene-hydrazino)-4-oxo-but-2-enoic acid methyl ester; 4-(4-Ethoxy-phenyl)-2-(N-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-but yric acid methyl ester; 2-(4-Bromo-phenylamino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester; A pharmaceutical composition is disclosed as well as the method of treating human and non-humans infected with M. tuberculosis and related mycobacteria.

Document Type

Patent

Patent Number

US 6,683,110

Application Serial Number

10/153,092

Issue Date

1-27-2004

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

CD3

Allowance Date

10-2-2003

Filing Date

5-20-2002

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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