Abstract
A method of making a hyperbranched amphiphillic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toulene sulphonic acid as a catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostics methods.
Document Type
Patent
Patent Number
US 8,372,944 B1
Application Serial Number
12/417,017
Issue Date
2-12-2013
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
NanoScience Technology Center
Department
NanoScience Technology Center
Allowance Date
6-22-2012
Filing Date
4-2-2009
Assignee at Filing
UCFRF
Filing Type
Nonprovisional Application Record
Donated
no
Recommended Citation
Perez Figueroa, J. Manuel and Santra, Santimukul, "Synthesis of Hyperbranched Amphiphylic Polyester and Theranostic Nanoparticles thereof" (2013). UCF Patents. 553.
https://stars.library.ucf.edu/patents/553