Title

Cerium Oxide Nanoparticle Based Device for the Detection of Reactive Oxygen Species and Monitoring of Chronic Inflammation

Abstract

A polymer-coated cerium oxide based device and system is disclosed for detecting reactive oxygen species and monitoring chronic inflammation. The device and system encapsulate free therapeutic nanoparticle elements not present in a living body in a prosthetic or implantable unit. In one embodiment, the unit is a structure with a reactive oxygen species (ROS) scavenging component on one end and at the opposite end is an imaging agent consisting of at least one of the fluorophore capable of fluorescence emission, a chemiluminescent agent, a magnetic relaxation agent and an X-ray contrast agent. In a second embodiment, a single chamber device consisting of a multifunctional nanocomposite has a ROS-scavenging nanoparticle constituent (nanoceria) and a multimodal reporting nanoparticle component (i.e. Dex-IR-DiR). The device and system is utilized in treatment of diseases with a pro-inflammatory component, including, but not limited to, Crohn's disease, ulcerative colitis, inflammatory bowel disease, cystic fibrosis, arthritis. Also, the device can be used to monitor and assess the potential induction of inflammation, such as in cancer therapy and antimicrobial therapies.

Document Type

Patent

Patent Number

US 8,795,731

Application Serial Number

12/924,976

Issue Date

8-5-2014

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

NanoScience Technology Center

Department

NanoScience Technology Center

Allowance Date

3-21-2014

Filing Date

10-8-2010

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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