Abstract
oxygen deprived never cells produce high levels of glutanate which stimulates the NMDA receptor know to cause cell death the ucf anthracene-polyamine derivative blocks NMDA receptor very efficiently with an IC50 (65nm) whereas a current drug now used in alzheimer treatments has an IC50 (460nm) our compound is therefore 7 times more potent and could lead to a new therapy for human diseases which involve the ndma receptor
Document Type
Patent
Patent Number
US 7,728,040 B1
Application Serial Number
12/151,823
Issue Date
6-1-2010
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
College of Sciences
Department
Chemistry
Allowance Date
3-17-2010
Filing Date
5-9-2008
Assignee at Filing
UCFRF
Filing Type
Nonprovisional Application Record
Donated
no
Recommended Citation
Phanstiel, Otto, "Polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs" (2010). UCF Patents. 777.
https://stars.library.ucf.edu/patents/777