Abstract

By studiying a series of polyamine anthacoe conjugates we have discovered the optimum architecture to selectively delivery drug cargoes to cancer cells using the polyamine transport system. The homospermidine analogue the (4,3) and (5,4) analogues all gave enhanced selectivity in delivering an appended anthracene drug into cancer cells. this marks the first time that a triamine structure has been identified as enhancing delivery of an appended cargo.

Document Type

Patent

Patent Number

US 7,001,925

Application Serial Number

10/667,288

Issue Date

2-21-2006

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

College of Sciences

Department

Chemistry

Allowance Date

11-22-2005

Filing Date

9-19-2003

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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