Abstract
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo.
Document Type
Patent
Patent Number
US 8,586,749
Application Serial Number
13/263,336
Issue Date
11-19-2013
Current Assignee
Joint Assignment w/UCFRF: University of Toronto
Assignee at Issuance
Joint Assignment w/UCFRF: University of Toronto
College
Burnett School of Biomedical Sciences
Department
Biomolecular Science Center
Allowance Date
8-8-2013
Filing Date
10-6-2011
Assignee at Filing
Joint Assignment w/UCFRF: University of Toronto
Filing Type
National Filing Record
Donated
no
Recommended Citation
Turkson, James and Gunning, Patrick, "Compounds that suppress cancer cells and exhibit antitumor activity (US)" (2013). UCF Patents. 97.
https://stars.library.ucf.edu/patents/97