The primate Alu family of repetitive elements has been widely characterized. This ubiquitous class of retroposons has been found to occupy some 5% of the human genome. This heterogenous group of Short Interspersed Nucleic add Elements (SINEs) has been theorized to possess an identifiable subfamily structure between and within various taxonomic levels in primates. It has been postulated that humans possess up to 6 Alu subfamilies in their genome; this number, however, has varied according to the method of analysis performed on the data. Quentin (1988) analyzed 127 aligned Alu sequences and found evidence supporting the amplification/fixation theory in 5 subfamilies. The research presented in this thesis posits that Quentin's method of alignment used in the correspondence analysis is questionable. A reexamination using an alternative, perhaps more tenable, alignment of the Alu sequences may allow for a more lucid and accurate identification of Alu subfamily structure in the human genome.
Sweet, Haven C.
Master of Science (M.S.)
College of Arts and Sciences
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Masters Thesis (Open Access)
York, William A., "Re-examining Subfamily Classifications For the Alu Family of Repeated DNA Sequences" (1994). Retrospective Theses and Dissertations. 3599.