Abstract

Patients with Acquired Immune Deficiency Syndrome (AIDS), AIDS-Related Complex (ARC) and other high-risk individuals were evaluated for lymphocyte subsets and serum levels of IgG, IgA, IgM, complement C3 and C4, B2-rnicroglobulin, circulating immune complexes and antibodies to HIV (1). Patients with other immunologic diseases not related to AIDS and healthy individuals not at risk for AIDS were also included in the study. AIDS-related patients overall showed significant (p < .05) relative and absolute decreases helper/inducer T cells, and relative and absolute increases in suppressor/ cytotoxic T cells, resulting in dramatic decreases in helper to suppressor ratios. Relative decreases in total T cells and increases in B cells and natural killer (NK) cells were also observed in some AIDSrelated patients. Four patients not at risk for AIDS had borderline and possibly false positive HIV antibody results. Antibody levels in one of these patients gradually changed to negative after a period of a few weeks. AIDS-related patients overall were also found to have significant (p < .05) increases in serum levels of imrnunoglobulins, B2-microglobulin, and circulating immune complexes. Significant changes in serum levels of Complement C3 and C4 were not observed.

Notes

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Graduation Date

1988

Semester

Fall

Advisor

White, Roseanne S.

Degree

Master of Science (M.S.)

College

College of Arts and Sciences

Department

Biological Sciences

Degree Program

Microbiology

Format

PDF

Pages

83 p.

Language

English

Rights

Public Domain

Length of Campus-only Access

None

Access Status

Masters Thesis (Open Access)

Identifier

DP0025771

Subjects

Arts and Sciences -- Dissertations, Academic; Dissertations, Academic -- Arts and Sciences

Accessibility Status

Searchable text

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Included in

Microbiology Commons

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