This research provides ultrastructural information regarding pulmonary surfactant secretion from stimulation of adrenergic pathways to the lung via the stellate ganglion. This information will help clarify the important role of the sympathetic nervous system in surfactant disorders. It also provides insight into sympathetic mechanisms causing surfactant derangement in adult and infant respiratory distress syndromes (RDS). Basic cellular mechanisms of surfactant metabolism, including synthesis and packaging in lamellar bodies, were studied. Results shed light on these basic processes of lung cell function.
The results of this study provide new avenues for studying a problem in health care that has long resisted advances, that of surfactant replacement therapy. It is expected that the results of this research, taken with information from other researches, will ultimately reduce the 50% mortality rate of the 150,000 patients annually suffering from RDS (Andreadis and Petty 1985).
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Crittenden, Daniel J.
Master of Science (M.S.)
College of Health
Length of Campus-only Access
Masters Thesis (Open Access)
Alexander, Lori Ann, "Influence of Stellate Ganglion Stimulation on Morphology of Alveolar Type II Cells" (1987). Retrospective Theses and Dissertations. 5047.
Contributor (Linked data)
Crittenden, Daniel J. [VIAF]