Title

Reactions Of Β-Fluorovinamidinium Salt With Bifunctional Hetero Nucleophiles. A New Synthetic Route To Fluorinated Heterocycles

Abstract

β-Fluorovinamidinium salt (2), readily prepared fromN-(2, 3, 3-trifluoro-1-propenyl)trimethyl-ammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluorinated pyrimidines4 in good yields. The one-pot procedure starting from1 was applicable for synthesizing heterocyclic compounds4 in almost comparable yields. © 1995 Elsevier Science Ltd.

Publication Date

2-27-1995

Publication Title

Tetrahedron Letters

Volume

36

Issue

9

Number of Pages

1527-1530

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/0040-4039(95)00076-O

Socpus ID

0028959333 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0028959333

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