Title

An Improved Synthesis of O-Benzoyl Protected Hydroxamates

Abstract

Several primary amines (R-NH2) were converted to their corresponding O-benzoyl protected hydroxamates under biphasic conditions. The intermediate (benzoyloxy)amines (R-NHOCOPh) were generated using benzoyl peroxide dissolved in CH2Cl2 and an aqueous carbonate buffer (pH 10.5) at room temperature. Subsequent acylation with R'COCl gave the protected hydroxamates (R'CONROCOPh) in good overall yields (56-89%).

Publication Date

1-1-1997

Publication Title

Journal of Organic Chemistry

Volume

62

Issue

23

Number of Pages

8104-8108

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/jo971126q

Socpus ID

0008970533 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0008970533

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