Title

Direct Imaging In A Water Layer Of Human Chromosome Fibres Composed Of Nucleosomes And Their Higher‐Order Structures By Laser‐Plasma X‐Ray Contact Microscopy

Keywords

contact microscopy; hydrated human chromosome fibre; Laser‐plasma X‐rays; nucleosome; superbead; unfixed; unstained

Abstract

X‐ray contact microscopy with a 300‐ps‐duration laser‐plasma X‐ray source has been used to image hydrated human chromosomes. Clearly imaged are individual nucleosomes and their higher‐order particles (superbeads), elementary chromatin fibrils c. 30 nm in diameter and their higher‐order fibres of various sizes up to c. 120 nm in diameter. The results demonstrate that X‐ray microscopy is now capable of opening a new path of investigation into the detailed structures of hydrated chromosome fibres in their natural state. 1994 Blackwell Science Ltd

Publication Date

1-1-1994

Publication Title

Journal of Microscopy

Volume

176

Issue

1

Number of Pages

63-74

Document Type

Review

Identifier

scopus

Personal Identifier

scopus

DOI Link

https://doi.org/10.1111/j.1365-2818.1994.tb03500.x

Socpus ID

0027937807 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0027937807

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