Title

Nanoscale Mechanics Of Solid-Supported Multilayered Lipid Films By Force Measurement

Keywords

Atomic force microscopy (AFM); Bilayer membrane; Lipid films; Nanomechanics; Solution spreading; Spin-coating; Structure and elastic properties; Young's modulus

Abstract

Using atomic force microscopy and molecular force probe, we have studied the structure and nanomechanical response to nano-indentation of multilayered films of dioleoylphosphatidylcholine films prepared by solution spreading, spin-coating, and capillary methods. The influence of the film thickness on the apparent elastic (Young's) modulus is investigated. Young's moduli of samples prepared by the different methods were found to be similar for sufficiently thick films. An ostensible influence of substrate coupling on the apparent Young's modulus is observed for thinner lipid films. The results are discussed in comparison with previously reported estimates for supported lipid bilayers (membranes) and cells. © 2008 Elsevier B.V. All rights reserved.

Publication Date

6-2-2008

Publication Title

Thin Solid Films

Volume

516

Issue

15

Number of Pages

5039-5045

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.tsf.2008.02.023

Socpus ID

42649108046 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/42649108046

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