Title

Radial Elasticity Of Self-Assembled Lipid Tubules

Keywords

Atomic force microscopy; Finite element analysis; Lipid tubules; Nanomechanics

Abstract

Self-assembled lipid tubules with crystalline bilayer walls represent useful supramolecular architectures which hold promise as vehicles for the controlled release of preloaded drugs and templates for the synthesis of one-dimensional inorganic materials. We study the local elasticity of lipid tubules of 1,2-bis(tricosa-10, 12-diynoyl)-sn-glycero-3-phosphocholine by radial atomic force microscope indentation, coupled with finite element analysis. A reduced stiffness is found to extend a distance of ∼600 nm from the ends of lipid tubules. The middle section of lipid tubules is homogeneous in terms of their radial elasticity with a Young's modulus of ∼703 MPa. The inhomogeneous radial elasticity likely arises from the variation of lipid packing density near the tubule ends. © 2008 American Chemical Society.

Publication Date

7-1-2008

Publication Title

ACS Nano

Volume

2

Issue

7

Number of Pages

1466-1472

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/nn8001517

Socpus ID

49249094983 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/49249094983

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