Title

Optical Coherence Microscope For Invariant High Resolution In Vivo Skin Imaging

Keywords

3D; C-scanning; Dynamic focusing; Lateral resolution; Optical coherence microscopy; Skin imaging

Abstract

A non-invasive, reliable and affordable imaging system with the capability of detecting skin pathologies such as skin cancer would be a valuable tool to use for pre-screening and diagnostic applications. Optical Coherence Microscopy (OCM) is emerging as a building block for in vivo optical diagnosis, where high numerical aperture optics is introduced in the sample arm to achieve high lateral resolution. While high numerical aperture optics enables realizing high lateral resolution at the focus point, dynamic focusing is required to maintain the target lateral resolution throughout the depth of the sample being imaged. In this paper, we demonstrate the ability to dynamically focus in real-time with no moving parts to a depth of up to 2mm in skin-equivalent tissue in order to achieve 3.5μm lateral resolution throughout an 8 cubic millimeter sample. The built-in dynamic focusing ability is provided by an addressable liquid lens embedded in custom-designed optics which was designed for a broadband laser source of 120 nm bandwidth centered at around 800nm. The imaging probe was designed to be low-cost and portable. Design evaluation and tolerance analysis results show that the probe is robust to manufacturing errors and produces consistent high performance throughout the imaging volume.

Publication Date

4-21-2008

Publication Title

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volume

6849

Number of Pages

-

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1117/12.763394

Socpus ID

42149140181 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/42149140181

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