Title

Mitochondrial Fragmentation In Neurodegeneration

Abstract

Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and dictate organelle shape, number and bioenergetic functionality. There is mounting evidence that mitochondrial dysfunction is an early and causal event in neurodegeneration. Mutations in the mitochondrial fusion GTPases mitofusin 2 and optic atrophy 1, neurotoxins and oxidative stress all disrupt the cable-like morphology of functional mitochondria. This results in impaired bioenergetics and mitochondrial migration, and can trigger neurodegeneration. These findings suggest potential new treatment avenues for neurodegenerative diseases. © 2008 Macmillan Publishers Limited. All rights reserved.

Publication Date

7-1-2008

Publication Title

Nature Reviews Neuroscience

Volume

9

Issue

7

Number of Pages

505-518

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/nrn2417

Socpus ID

45749117188 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/45749117188

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